RF、CRP和抗-CCP抗体联合检测对类风湿关节炎的诊断意义

Diagnosis values of combined determination of serum rheumatoid factor,C reaction protein and anti-CCP antibody in patients with rheumatoid arthritis

目的探讨类风湿因子(RF)、C反应蛋白(CRP)和抗环瓜氨酸肽(抗-CCP)抗体联合检测对类风湿关节炎(RA)的诊断意义。方法对60例RA患者和60例其他风湿类疾病患者进行RF和CRP以及抗-CCP抗体检测,应用速率散射比浊法测定CRP、RF,应用ELISA法测定抗-CCP抗体。结果60例患者血清中,RF灵敏度和特异性分别为67%和77%,CRP灵敏度和特异性分别为83%和33%,抗-CCP抗体灵敏度和特异性分别为72%和95%,三项联合检测灵敏度和特异性分别为98%和22%。结论RF、CRP和抗-CCP抗体三项指标联合检测可明显提高对RA的诊断灵敏性,有助于RA的诊断。

Objective It is to approach the diagnosis value of combined determination of serum rheumatoid factor （RF）, c-reaction protein （CRP） and anti-cyclic citrulline peptide （anti-CCP） antibody in patients with rheumatoid arthritis （RA）. Methods The RF and CRP were detect by rate-nephelometry and the anti-CCP was measured by enzyme-linked immunosorbent assay in 60 patients with RA and in 60 patients with other rheumatic diseases. Results The diagnostic sensitivities of RF, CRP and anti-CCP were 67 % , 83 % and 72 % respectively, and specificities were77 % , 33 % and 95 % respectively. The specificity was 22 % and the sensitivity was 98 % with combined determination of RF, CRP and anti-CCP. Conclusion While RF, CRP and anti-CCP may offer clinical benefits for diagnosis of RA, combined with determination can significantly improve the sensitivity to diagnose RA.