尿畅舒胶囊对绝经后尿道综合征尿流动力学的影响

Effect of Niaochangshu Capsule on Urodynamics of Patients with Post-menopause Urethral Syndrome

目的观察尿畅舒胶囊对肾虚血瘀型绝经后尿道综合征患者膀胱充盈期尿流动力学指标的影响。方法采用随机对照、双盲双模拟的方法,选取肾虚血瘀型绝经后尿道综合征患者36例,分为尿畅舒胶囊治疗组(24例)和尼尔雌醇对照组(12例),分别给予尿畅舒胶囊及尼尔雌醇片治疗8周,观察治疗前后各组患者膀胱容量、膀胱顺应性等膀胱充盈期尿流动力学指标的变化。结果治疗组及对照组患者最大膀胱容量、初始尿意容量、膀胱顺应性等膀胱充盈期尿流动力学指标较治疗前均有明显改善,差异有统计学意义(P<0.05)。治疗组和对照组比较,差异无统计学意义(P>0.05)。结论尿畅舒胶囊治疗肾虚血瘀型绝经后尿道综合征,能有效增加患者膀胱容量,提高膀胱顺应性,降低膀胱敏感性,疗效与尼尔雌醇相仿。

Objective To investigate the effect of Niaochangshu capsule on urodynamics in bladder filling period of patients with post-menopause urethral syndrome of renal deficiency and blood stasis type. Methods A total of 36 patients with post-menopause urethral syndrome of renal deficiency and blood stasis type were randomly assigned to two groups： the trial group （24 patients were treated with Niaochangshu capsule） and the control group （12 patients were treated with Nilestriol）. All patients were treated for 8 weeks. The changes of the urodynamic indexes in bladder filling period （the capacity of the bladder, the compliance of the bladder and the sensitivity of the bladder） were compared between the two groups. Results After treatment, the urodynamic index, including the maximum cystic capacity, the volume at the first desire to void and the cystic compliance were evidently improved in both of the trial group and the control group （P〈0.05）. There was no statistical difference between the two groups （P〉0.05）. Conclusion Niaochangshu capsule is effective in treating the patients with post-menopause urethral syndrome of renal deficiency and blood stasis type. It can increase the cystic capacity and compliance, step down the sensitivity of the bladder. Its effect is similar to Nilestriol.