大环内酯类药物对绿脓杆菌作用的研究

Study on the Effect of Macrolide on Pseudomonas Aeruginosa

目的重新认识大环内酯类药物对绿脓杆菌作用的机理。方法通过CAJ文献数据库检索;从大环内酯类药物对绿脓杆菌的抗菌作用原理的角度来分析研究。结果大环内酯类药物对绿脓杆菌感染的作用不是通过经典的核糖体途径(与细菌核糖体的50S亚基结合,从而抑制细菌蛋白质合成),而是通过免疫调节、抗炎作用和抑制细菌毒力的作用来抑制或杀灭绿脓杆菌。结论大环内酯类药物用于治疗支气管炎、支气管囊性纤维化(CF)、支气管扩张症、慢性副鼻窦炎、烧伤并发的绿脓杆菌等疾病的治疗,疗效显著。

OBJECTIVE The restudy of mechanism of macrolide drugs on pseudomonas aeruginosa （PA） is of high guidance for clinically treating PA infection and doing basic research. METHODS Retrieval through CAJ bibliographic database, analysis and research from the view of the antibacterial action mechanism of macrolide drugs on PA. RESULTS The action mechanism of macrolide drugs on PA infection is not through classic ribosomes （to combine with 50S subunits in bacterial ribosomes so to restrain the synthesis of bacterial protein） but to restrain or kill PA through immune regulation, anti-inflammation and inhibition of bacterial virulence. CONLUTSION Macrolide drugs are effective in treatment of bronchitis, cystic fibrosis （CF）, bronchiectasis, chronic paranasal sinusitis （CPS）, burn complications of PA.