^(131)I对甲状腺功能亢进症患者早期唾液溶菌酶含量及pH值的影响

THE EFFECT OF TREATMENT EITH RADIO IODINE 131 ON THE CONTENT OF SALIVARY LYSOZYME AND THE SALIVA PH VALUE IN PATIENTS WITH HYPERTHYROIDISM

目的：探讨甲状腺功能亢进症病人经１３１Ｉ治疗后唾液非特异免疫功能的变化。方法：检测并比较４９例病人１３１Ｉ治疗前和治疗后第１、３、７天唾液溶菌酶（ＳａｌｉｖａｒｙＬｙｓｏｚｙｍｅ，ＳＬｙ）含量及唾液ｐＨ值。结果：１３１Ｉ治疗后第１天ＳＬｙ含量开始下降，到第３天显著低于治疗前（０．０１＜Ｐ＜０．０２），到第７天恢复正常。ＳＬｙ的变化在治疗剂量范围内，与１３１Ｉ剂量大小无关（Ｐ＞０．０５）。ｐＨ值治疗前后比较无显著性差异（Ｐ＞０．０５）。结论：治疗剂量１３１Ｉ可引起甲状腺功能亢进症病人ＳＬｙ含量的暂时性下降。

Objective:To investigate the effects of treatment with iodine 131 on the Non specific immunofunctional changes of saliva in patients with hyperthyroidism.Methods:Detection and comparision the content of salivary lysozyme(SLy)and the saliva pH value before and 1,3,7 days after treatment in 49 cases.With hyperthyroidism were performed.Results:The content of salivary SLy began to decrease 1 day after treatment.It was lower significantly in the third day after treatment than before(0 01<P<0 02),and returned to normal in the 7 day after treatment.These changes did not relate to the doses of Iodine 131 used(P>0 05).The saliva pH value was not different comparing before and after treatment.Conclusions:The results showed that treatment dose of iodine 131 could cause the content of SLy temporarily decrease in patients with Hyperthyroidism,but it did not relate with the doses used.