乳腺癌患者术后检测血清可溶性白介素-2受体的临床意义

CLINICAL SIGNIFICANCE OF SERUM SOLUBLE INTERLEUKIN 2 RECEPTOR(sIL 2R) IN PATIENTS WITH BREAST CANCER AFTER OPERATION

目的：探讨血清可溶性白细胞介素－２受体（ＳｏｌｕｂｌｅＩｎｔｅｒｌｅｕｋｉｎ－２Ｒｅｃｅｐｔｏｒ，ｓＩＬ－２Ｒ）与乳腺癌患者病期及预后的关系。方法：采用ＥＬＩＳＡ法，检测８６例乳腺癌术后患者血清ｓＩＬ－２Ｒ水平。结果：乳腺癌患者术后血清ｓＩＬ－２Ｒ水平明显高于正常对照组（Ｐ＜０．０１），而术后复发转移组明显高于无荷瘤的治愈组（Ｐ＜０．０１）。Ⅲ期乳腺癌患者明显高于Ⅰ、Ⅱ期患者（Ｐ＜０．０１），但与病理类型无明显关系。结论：乳腺癌患者术后血清ｓＩＬ－２Ｒ的表达与肿瘤的临床分期及复发转移密切相关。

Objective:To investigate the relationship between the serum soluble interleukin 2 receptor(sIL 2R)and the stage and prognosis of patients of breast cancer.Methods:Using the method of sandwich ELISA,the sIL 2R in 86 case of breast cancer after operation was measured.Results:The serum sIL 2R levels in the patients with breast cancer after operation are significantly higher than that of the ontrols (P<0 01);it is significiantly higher in the group of the relapse with metastasis following operation than the of recovery group withowt bearing carcinoma(P<0 01).The stage Ⅲ also remarkly higher than both stage I and Ⅱ in sIL 2R(P<0 01),but it isn't related to the pathologic. Typy of cancer.Conclusion:The expression of the serum sIL 2R in patients with breast cancer after operation is closely related to the clinical stage,the recidivism and metastasis.It could be used as a marker in the assessment of stage and prognosis in the breast cancer patient.