Nod样受体与Toll受体介导炎症的研究进展

Progress in the study of TLRs- and NLRs-mediated inflammation

固有免疫系统是抵御微生物入侵的第一道防线，它依赖模式识别受体识别外源病原微生物然后将其清除。Toll样受体（TLR）和Nod样受体（NLR）是介导免疫识别的重要受体，其通过识别病原体相关分子模式不仅启动了固有免疫应答，而且激活了适应性免疫应答，是连接固有免疫和适应性免疫的桥梁。中性粒细胞是机体早期炎症反应中最重要的炎症细胞，其粘附、活化及凋亡的整个过程可受TLR的调节，促成炎症反应的无损伤性收敛，使机体维持内环境的稳态。

Innate immunity system is the first line of defense against microbial invasion. It recognizes and removes pathogenic microorganisms through the host pattern recognition receptors （PRRs）. Toll-like receptors （TLRs） and Nod-like receptors （NLRs） can mediate immune recognition. Since the two important receptors not only initiate the innate immune responses but also stimulate the adaptive immunity responses through pathogen-associated molecular patterns （PAMPs）, they are linking the innate and adaptive immunity. Poly- morphonuclear neutrophils （PMNs） are the most important inflammatory cells in the early inflammation. TLRs play a crucial role in the processes of adhesion, activation and apoptosis of PMNs so as to maintain the stability of the internal environment.