摘要
固有免疫系统是抵御微生物入侵的第一道防线,它依赖模式识别受体识别外源病原微生物然后将其清除。Toll样受体(TLR)和Nod样受体(NLR)是介导免疫识别的重要受体,其通过识别病原体相关分子模式不仅启动了固有免疫应答,而且激活了适应性免疫应答,是连接固有免疫和适应性免疫的桥梁。中性粒细胞是机体早期炎症反应中最重要的炎症细胞,其粘附、活化及凋亡的整个过程可受TLR的调节,促成炎症反应的无损伤性收敛,使机体维持内环境的稳态。
Innate immunity system is the first line of defense against microbial invasion. It recognizes and removes pathogenic microorganisms through the host pattern recognition receptors (PRRs). Toll-like receptors (TLRs) and Nod-like receptors (NLRs) can mediate immune recognition. Since the two important receptors not only initiate the innate immune responses but also stimulate the adaptive immunity responses through pathogen-associated molecular patterns (PAMPs), they are linking the innate and adaptive immunity. Poly- morphonuclear neutrophils (PMNs) are the most important inflammatory cells in the early inflammation. TLRs play a crucial role in the processes of adhesion, activation and apoptosis of PMNs so as to maintain the stability of the internal environment.
出处
《国际免疫学杂志》
CAS
北大核心
2009年第5期345-349,共5页
International Journal of Immunology
基金
国家自然科学基金资助项目(30371305)
关键词
TOLL样受体
NOD样受体
中性粒细胞
Toll-like receptors
Nod-like receptors
Polymorphonuclear neutrophils