NF-κB信号通路基本元件调节机制的研究进展

Progress on the regulation of basic elements of NF-κB signaling pathway

核因子-kappaB（NF-κB）信号通路广泛参与调节免疫反应、炎症反应、细胞分化与凋亡、肿瘤形成等多种生物学功能。在非激活细胞中，NF-κB转录因子通常与其抑制物结合形成复合物，并在胞浆与胞核间达到平衡，但这种复合物主要存在于胞浆中。当受到胞外信号刺激后，复合物可以在NF—κB信号通路的多个信号转导途径中发生降解，使得抑制物从复合物中解离，释放出的大量活性NF—κB迅速转移入核，从而调控相应靶基因的表达。目前发现的和NF—κB的调节紊乱有关的疾病谱在不断扩大，这也使得对于NF—κB信号通路功能和调节的研究得到了深入发展，对通路中一些基本元件的调节也有了较为充分的了解。

ses, including the immune and inflammatory responses, cell growth, apoptosis, and tumour formation. In unstimulated cells, NF-κB usually binds with its inhibitor to form a complex which can reach a dynamic equilibrium state between the cytoplasm and the nucleus, while most of the complexs reside in the cytoplasm. With stimuli from extracell, a serial of kin ases are actived and lots of proteins will be oligomerization through several signaling pathways, subsequently increasing the level of NF-κB in nucleus by dismissing the inhibitor from NF-κB, which activaies the transcription of target genes. Since a wide range of diseases were found to be associated with the dysregulation of NF-κB signaling pathway,the function and regulation of this signaling pathway has been stndied extensively.