4-1BB／4-1BBL在T细胞免疫应答及疾病发生中的作用

The role of 4-1BB/4-1BBL in T-cell immune regulation and in the pathogenesis of related diseases

共刺激分子4-1BB和4-1BB配体（4-1BBL）属于肿瘤坏死因子／肿瘤坏死因子受体（TNF／TN—FR）超家族的重要成员，分别表达在活化的T细胞及树突状细胞（DC）上。4-1BB与4-1BBL相互作用产生的共刺激信号能够促进T细胞增殖、分化以及细胞因子的产生。4-1BB／4—1BBL信号途径在自身免疫性疾病、肿瘤、病毒感染等疾病的发生、发展过程中起着重要的免疫调节作用。干预调节4-1BB／4-1BBL信号途径有望为疾病的免疫治疗提供新的思路。

4-1BB and its cognate ligand （4-1BBL） are important members of TNF/TNFR supfamily of cosZ timulatory molecules. They are mainly expressed in T lymphocytes and dendritic cells. 4-1BB/4-1BBL interaction may enhance T lymphocyte proliferation, differentiation and cytokine production. The positive regulatory role of 4-1BB has also been. documented in human diseases, including autoimmune diseases, cancer and viral infection. Delineation of the complex interactions between 4-1BB and its ligand is critical for understanding this new immunoregulatory system. Precise manipulation of 4-1BB/4-1BBL costimulatory pathway may provide unique approaches for immunotherapy.