摘要
目的分析中国(未包括香港、澳门特别行政区和台湾地区,下同)不同年龄和免疫状态人群乙型肝炎(乙肝)病毒(Hepatitis Virus,HBV)血清学标志物检测组合模式。方法在全国160个疾病监测点,采用多阶段随机抽样方法,抽取1～59岁常住人口作为调查对象。问卷调查后,采集血标本,分离血清后用酶联免疫吸附试验检测乙肝病毒表面抗原(Hepatitis B Surface Antigen,HBsAg)、抗乙肝病毒表面抗原抗体(Anti-hepatitis B Surface Antibody,Anti-HBs)、抗乙肝病毒核心抗原抗体(Anti-hepatitis B Core Antibody,Anti-HBc)。对HBsAg阳性标本进行乙肝病毒e抗原(Hepatitis B e Antigen,HBeAg)和抗乙肝病毒e抗原抗体(Anti-hepatitis B e Antibody,Anti-HBe)检测。结果全国1～59岁人群HBsAg、Anti-HBs、Anti-HBc、HBeAg、Anti-HBe的组合模式共检测出16种,在1～4岁儿童以单纯Anti-HBs为主,占69.77%;15～59岁人群以全阴性检测结果多见。有免疫史人群中,年龄越大,Anti-HBs检出率越低;未免疫人群除检测指标以全阴性和单纯Anti-HBs外,自然感染所致的标志物多见。结论检测结果为其他流行病学调查提供了参考,可分析不同年龄、不同免疫史人群HBV血清学标志物的检出情况。
Objective To summarize the combination profile of hepatitis B markers by age and immunization history of Chinese. Methods Population of age 1-59 years were sampled from 160 counties of National Disease Surveillance in 31 provinces by multi-stage random sampling method. Demographic information and hepatitis B vaccination history was collected by questionnaire,and 2-4ml serum sample was taken for testing HBsAg,Anti-HBs and Anti-HBc by ELISA method. Results 16 combinations of hepatitis B markers （HBsAg,Anti-HBs,Anti-HBc,HBeAg and Anti-HBe） were found during the testing,anti-HBs was mainly found among 1-4 years old children,accounted 69.77%. Among 15-59 years,negative markers were mainly profi le. Among immunized population,the older,the lower rate of anti-HBs,while among un-immunized population,except negative for all markers and anti-HBs were observed,Infected markers was account for high proportion. Conclusion The prof ile could be used for guiding the laboratory testing by different ep.idemiologic characteristics,and can provide information for reference.
出处
《中国疫苗和免疫》
CAS
2009年第4期294-299,共6页
Chinese Journal of Vaccines and Immunization
基金
国家科学技术攻关课题"我国乙型病毒性肝炎流行规律和防治对策研究"(课题号:2004BA718B01)
