甲型肝炎减毒活疫苗与灭活疫苗免疫原性及其影响因素

The Immunogenicity and Impact Factors of Hepatitis A Attenuated Live Vaccine and Inactivated Vaccine

甲型病毒性肝炎(甲肝)是全球性公共卫生问题,也是中国控制的重点传染病之一。为加强甲肝控制,2007年中国将甲肝疫苗(Hepatitis A Vaccine,HepA)纳入了扩大免疫规划。现就中国目前应用的甲肝减毒活疫苗、国产和进口的甲肝灭活疫苗的免疫原性特点、主要影响因素以及中国HepA的使用现状等进行简要综述。

Hepatitis A is one of the global public health problems,and China has high prevalence. In order to decrease the incidence of hepatitis A,China has integrated Hepatitis A vaccine into Expanded Program on Immunization （EPI） in 2007. The paper will provide some ideas on the immunogenicity and impact factors of the different types of hepatitis A vaccines that are used in China.