小剂量氟哌啶预防腹腔镜胆囊摘除术后恶心呕吐的研究

Low-Dose Droperidol Prevents Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy

研究麻醉时用小剂量（1．0mg）氟哌啶对腹腔镜胆囊摘除术（LC）术后恶心呕吐的预防效果及其不良反应。方法：观察78例LC病人，用药组38例，对照组40例，对比术中平均动脉压（MAP）、HR、麻醉恢复室（PACU）评分、术后恶心呕吐发生率等。结果：用药组恶心呕吐发生率（13．2％）明显低于对照组（32．5％）（P＜0．05），MAP、HR、PACU评分在组间无显著差异。结论：小剂量氟哌啶能有效预防LC术后恶心呕吐，对麻醉无明显影响。

Objective: To evaluate the efficacy and adverse effects of low-dose droperidol(1. 0 mg) in preventing postoperative nausea and vomiting (PONV) of laparoscopic cholecystectomy (LC). Methods: Seventy-eightLC patients under standardized anesthesia were randomly divided into a prophylactic group (n= 38) and a controlgroup (n= 40). Parameters studied included MAP,HR changes in surgery, post-anesthesia care unit (PACU),score and PONV episodes after surgery recorded by ' blinded' nurses. Results: The incidence of PONV in theprophylactic group (13. 5 % ) was significantly lower than that of the control group (32. 5 % ), (P<0. 05). MAP,HR in surgery, PACU score and PACU observation time showed no significant difference between the twogroups (P>0.05 ). Conclusion: Low-dose droperidol (1. 0 mg ) administered in anesthesia reduces the incidenceof PONV of LC with neither circulation interference in surgery nor recovery delay of anesthesia.