高血压病家族遗传因素与易患危险因素聚集性的关联

Association Between Genetic Factors of Hypertension and the Clustering of Risk Factors of Sensitivity

目的探讨高血压病家族遗传因素与易患危险因素聚集性的关联。方法对４０个家系（２０个高血压病家系，含直系亲属１１８人，２０个对照家系，含直系亲属１１５人）进行高血压病家族遗传因素与易患危险因素聚集性的对比研究。结果两组家系有良好的均衡可比性。高血压病家系一级亲属患病率为４２．８％，与对照家系的１６．１％相比，有非常显著性差异。多因素Ｌｏｇｉｓｔｉｃ回归分析提示，９个易患危险因素中按入选的４个因素的危险程度大小依次为超重、高甘油三脂、脑力劳动及吸烟。两项分布分析显示，高血压病易患危险因素在高血压家系呈明显的家族聚集性。

Objective To explore the relationship between hypertension-prone genetic factors and the clustering of risk factors of seneitivity.Method A comparision study was carried out between hypertension-prone genetic factors and risk factors of sensitivity in 40 pedigrees which include 20 hypertinsis (118 direct relatives)and 20 normotensives (115 direct relatives) respectively.Result Indication showed that the family members in both cases and control groups were comparable.The incidence of primary relatives was 42.8%,significantly higher than that noticed in controls,whose incidence was 16.1%.Multivariate logistic regression analysis revealed that among the nine risk factors of sensitivity,the ordinal risk was overweight,hypertriglyceridemia,brain work and smoking.It showed from binominal distribution analysis that there was significant familial agregation in the gentic factors of hypertension.Conclusion The resuls supported the hypothesis that hypertension-prone gentic factors play an important role in the clustering of sensitive risk factors.