膀胱癌碱性成纤维细胞生长因子表达的意义及其与增殖细胞核抗原的关系

The implication of bFGF expression in bladder cancer and its relationship with PCNA.

目的探讨碱性成纤维细胞生长因子(bFGF)在膀胱癌中表达及其作用以及与增殖细胞核抗原(PC-NA)之间的关系。方法应用免疫组化方法检测膀胱癌和正常膀胱组织中两者表达。结果膀胱癌中bFGF表达显著高于正常组织,而且与肿瘤的病理分期分级、复发及大小之间有密切关系,但与PCNA表达之间无显著相关关系。结论 bFGF异常表达在膀胱癌发生发展过程中起重要作用,而且可以作为肿瘤生物学行为和复发的预示标记物,但其促进肿瘤细胞增殖的作用并不显著。

Objective To investigate the roles of basic fibroblast growth factor (bFGF) in the pathogenesis of bladder cancer and its relationship with tumor biological characteristics and PCNA. Methods The immunohistochemical method was used to examine the expression of bFGF and PCNA in 21 normal bladder tissues and 72 cases of bladder cancer respectively. Results The bFGF expression of bladder cancer was higher than that of normal tissues and had a positive relationship with tumor grade, stage, recurrence and size, but had no significant relationship with the expression of PCNA. Conclusion The overexpression of bFGF may play an important role in the development of bladder cancer and may be a useful marker for evaluation of tumor biological behavior and recurrence. However, its promotion on tumor cell proliferation was not significant.