猪胰肾联合移植模型的建立

Establishment of a model of combined pancreas-kidney transplantation in pig.

目的建立一种猪胰肾联合移植模型。方法血管吻合采用供体门静脉远端与左肾静脉端端吻合,近端再与受体下腔静脉端侧吻合;带腹腔动脉、肠系膜上动脉和左肾动脉的腹主动脉段与受体腹主动脉端侧吻合。胰腺外分泌自膀胱引流,供肾输尿管置管外引流。结果 11例动物移植成功,早期移植功能恢复良好。结论这种建立猪胰肾联合移植的方法是可行的。

Objective The model of combined pancreas-kidney transplantation was established in pig. Methods A renoportal end-to-end anastomosis between the left renal vein and the distal end of portal vein were performed. Only two vascular end-to-side anastomoses between the donor portal vein and recipient inferior vena cave, and between the donor aortic segment including the celiac, superior mesenteric, and left renal arteries and recipient abdominal aorta were constructed. Pancreas exocrine secretion drainage was established with duodenocystostomy. The uretherostomosis of the graft was performed. Results Satisfactory results were obtained in 11 pigs. Conclusion The method for combined pancreas-kidney transplantation was reliable.