涎腺良、恶性多形性腺瘤中ras癌基因产物P_(21)的表达

Expression of Ras -P_(21) in Benign and Malignant Pleomorphic Acenoma of Salivary

采用免疫组化Ｓ－Ｐ法对７７例涎腺良性多形性腺瘤与１１例恶性多形性腺瘤的ｒａｓ－Ｐ２１表达状况进行了观察．结果：良性多形性腺瘤ｒａｓ－Ｐ２１表达阳性率为１９４８％（１５／７７），恶性者为６３６３％（７／１１）．两者经χ２检验，阳性率差异有非常显著意义（Ｐ＜０００５）．提示：恶性涎腺多形性腺瘤的发生，可能与ｒａｓ－Ｐ２１激活有关．可用于临床诊断与估计预后的参考．而良性多形性腺瘤的阳性表达是否可作为其复发与恶变的表示，尚待进一步研究．

Expression of ras - P_(21) in 77 cases of benign pleomorphic adenoma and 11 cases of malignant pleomorphic adenoma were observed by using S - P immunohstochemical method.The results showed that the positive expression rate of the ras - P_(21) of the benign pleomorphic adenoma was 19.8% (15/77) and the positive expression rate of the ras- P_(21) of the malignant pleomorphic adenoma was 63.63% (7/11 ).The difference between two expressions through χ2 test was very signifiant (P<0.005 ).The results indicate that the incidence of malignant pleomorphic adenoma may be relative to the activation of ras - P_(21). Therefore above - mentioned results could be helpful to the diagnosis and prognosis of this adenoma.