盐酸氟桂嗪及维生素C对离体大鼠心脏缺血再灌注血流动力学的影响

Effects of Flunarizine and Vitamine C on Hemodynamicsin Rat Heart Subjected to Ischemiareperfusion

采用Ｌａｎｇｅｎｄｏｒｆ离体大鼠心脏灌注，研究全心缺血１０分钟、再灌注１５分钟后，心率、左室发展压、冠脉流率和心电图的变化，以及钙离子拮抗剂盐酸氟桂嗪（ＦＮＺ）和／或氧自由基清除剂维生素Ｃ（Ｖｉｔ．Ｃ）对上述指标的影响。结果发现，ＦＮＺ具冠脉扩张（Ｐ＜０．０１）及轻微负性心率作用；对左室发展压无影响。Ｖｉｔ．Ｃ对心率、左室发展压和冠脉流率均无影响。再灌注１０分钟时，ＦＮＺ＋Ｖｉｔ．Ｃ组、Ｖｉｔ．Ｃ组和ＦＮＺ组的心率与左室发展压乘积（率压积）均显著高于对照组（Ｐ＜０．０５）。提示ＦＮＺ和Ｖｉｔ．Ｃ均可改善再灌注后心脏功能的恢复。

Langendorff perfusion isolated rat heart was subjected to total global ischemia (coronary flow rate is equal to zero) for 10 minutes and reperfusion for 15 minutes. The heart rate (HR), left ventricular developed pressure (LVDP), coronary flow rate (CFR), electrocardiogram (ECG) and the effects of calcium antagonistflunarizine (FNZ) and/or oxygen free radical scavenger—vitamine C on the above parameters were observed. The results showed that FNZ dilated coronary vessel (P<001) and had a slight negative chronotropic effect, but it had no effect on LVP.Vitamine C did not affect HR, LVP and CFR. The recovery of the product of HR and LVDPRate Pressure Product (RPP) in the FNZ+Vit.C group, Vit.C group and FNZ group was significantly higher than that in the control group (P<005) at ten minutes reperfusion. All the results suggest that FNZ and Vit.C may improve the recovery of heart function after reperfusion.