血浆内皮素-1、醛固酮在肾病综合征患儿钠潴留中的作用

Eeffects of Plasma Endothelin1 and Aldosterone on SodiumRetention in Children with Nephrotic Syndrome

为探讨血浆内皮素－１（ＥＴ－１）和醛固酮（Ａｌｄ）在肾病综合征患儿钠潴留中的作用，对１４例肾病综合征患儿在水肿期和消肿期的血浆ＥＴ－１、Ａｌｄ及血清渗透压、白蛋白（Ａｌｂ）、Ｎａ＋的变化进行了观测。结果显示患儿水肿期血浆ＥＴ－１比消肿期显著性升高（Ｐ＜０．０１），水肿期血浆Ａｌｄ与消肿期无明显差异（Ｐ＞０．０５）；血浆ＥＴ－１与血清Ｎａ＋呈直线正相关（ｒ＝０．４８６，Ｐ＜０．０１），与血清Ａｌｂ呈直线负相关（ｒ＝－０．４９０，Ｐ＜０．０１）。提示肾病钠潴留可能与肾排钠减少有关，ＥＴ－１在其中起了重要作用。

The effects of plasma endothelin1 (ET1) and aldosterone (Ald) on sodium retention in children with nephrotic syndrome were investigated. 14 cases were divided into the edematous stage and nonedematous stage. Plasma ET1, Ald, and serum osmolarity, albumin (Alb), and Na+ were measured in each stage. The results showed that the plasma ET1 in edemaous stage increased significantly, compared with that in noedematous stage (P<0.01). There was no significant difference in plasma Ald between the edematous stage and the nonedematous stage. Plasma ET1 was positively correlated with the serum sodium ionic concentration and negatively correlated with the serum Alb(r=0.486,P<0.01; r=0.490, P<0.01, respectively). In conclusion, the sodium retention with nephrotic syndrome might be correlated with reduction of secreted sodium in the kidney, suggesting that ET1 plays an important role in pathogenesis