摘要
为探讨血浆内皮素-1(ET-1)和醛固酮(Ald)在肾病综合征患儿钠潴留中的作用,对14例肾病综合征患儿在水肿期和消肿期的血浆ET-1、Ald及血清渗透压、白蛋白(Alb)、Na+的变化进行了观测。结果显示患儿水肿期血浆ET-1比消肿期显著性升高(P<0.01),水肿期血浆Ald与消肿期无明显差异(P>0.05);血浆ET-1与血清Na+呈直线正相关(r=0.486,P<0.01),与血清Alb呈直线负相关(r=-0.490,P<0.01)。提示肾病钠潴留可能与肾排钠减少有关,ET-1在其中起了重要作用。
The effects of plasma endothelin1 (ET1) and aldosterone (Ald) on sodium retention in children with nephrotic syndrome were investigated. 14 cases were divided into the edematous stage and nonedematous stage. Plasma ET1, Ald, and serum osmolarity, albumin (Alb), and Na+ were measured in each stage. The results showed that the plasma ET1 in edemaous stage increased significantly, compared with that in noedematous stage (P<0.01). There was no significant difference in plasma Ald between the edematous stage and the nonedematous stage. Plasma ET1 was positively correlated with the serum sodium ionic concentration and negatively correlated with the serum Alb(r=0.486,P<0.01; r=0.490, P<0.01, respectively). In conclusion, the sodium retention with nephrotic syndrome might be correlated with reduction of secreted sodium in the kidney, suggesting that ET1 plays an important role in pathogenesis
出处
《华西医科大学学报》
CSCD
1998年第3期320-322,共3页
Journal of West China University of Medical Sciences