干燥综合征与恶性淋巴瘤

Sj¨ogren's Syndrome and Malignant Lymphoma

为了探索早期诊断干燥综合征患者合并恶性淋巴瘤，作者采用Ｂ细胞恶性淋巴瘤基因探针检测了４例干燥综合征患者的泪腺组织及患眼附属器Ｂ恶性淋巴瘤组织。结果４例干燥综合征患者泪腺组织阴性，而５例恶性淋巴瘤患者的瘤组织扩增阳性。结果表明，一般的原发或继发性干燥综合征患者泪腺中的淋巴细胞中无恶性Ｂ淋巴瘤基因。

To diagnose and study the early stage of Sj¨ogren's syndrome associated with malignant lymphoma, the authors used the PCR technique of B malignant lymphoma gene for lacrimal gland tissues in four patients with Sj¨ogren's syndrome and in five patients suffering from B malignant lymphoma. The results showed that all cases of Sj¨ogren's syndrome were negative and all cases of B malignant lymphoma were positive. These suggest that in general the patients with primary or secondary Sj¨ogren's syndrome have no malignant lymphoma genes, but those who have chronic fever and enlarged superficial lymph nodes should under go this technique for early diagnosis and treatment of Sj¨ogren's syndrome associated with malignant lymphoma.