沙土鼠缺血再灌注时红细胞β-内啡呔对红细胞免疫粘附功能调控的研究

A study of the regulation of RBCβ-EP to RCIA during cerebral ischemia reperfusion in gerbil.

目的探讨沙土鼠缺血再灌注时红细胞β－内啡呔（β－ｅｎｄｏｒｐｈｉｎβ－ＥＰ）对红细胞免疫粘附功能（ＲｅｄｃｅｌｉｍｍｕｎｅａｄｈｅｒｅｎｃｅＲＣＩＡ）有否调控作用。方法采用蒙古种沙土鼠缺血再灌注模型分别测定ＲＣＩＡ以及红细胞β－ＥＰ（ＲＢＣ－β－ＥＰ）含量，观察两者相互关系，进一步探讨其发生机制。结果显示单纯缺血时ＲＢＣ－β－ＥＰ含量轻度升高，但ＲＣＩＡ降低不明显；而再灌注时随红细胞β－ＥＰ含量明显升高，ＲＣＩＡ功能降低明显。结论在缺血再灌注时，一定浓度的ＲＢＣ－β－ＥＰ对红细胞免疫有促进作用，而高浓度时则有抑制作用。

Objective To study the effects of the RBCβ-EP regulated red cell immune adherence (RCIA) during cerebral ischemia reperfusion in gerbil.Methods RCIA and RBCβ-EP were determined respectively by means ofgerbil.Rusults RBCβ-EP increased slightly while RCIA didn't change markly during cerebral ischemia,with RBCβ-EP significantly increasing,RCIA decreased obviously during cerebral ischemiareperfusion.Conclusion RBCβ-EP promoted the function of RCIA,excessive amounts of β-EP inhibited the function of RCIA.The suggests that blocking β-EP production can contributes to improve the function of RCIA.