犬蛛网膜下腔出血后脑血管痉挛血浆和脑脊液中NT含量的动态变化

Levels of neurotensin in plasma and CSF on CVS following experimental dog SAH

目的探讨蛛网膜下腔出血（ＳＡＨ）后脑血管痉挛（ＣＶＳ）时血和脑脊液中神经降压素（ＮＴ）的变化规律及作用。方法采用放免技术动态观察了犬ＳＡＨ后血浆、ＣＳＦ中ＮＴ含量动态变化。结果ＳＡＨ组血浆、脑脊液中ＮＴ含量增高。血浆中ＮＴ在注血后２天开始增高，第７天最高（Ｐ＜０．０１）。脑脊液中ＮＴ在注血后３０ｍｉｎ即显著增高（Ｐ＜０．０１），第７天最高。结论ＮＴ可能参与了ＳＡＨ后ＣＶＳ的过程。

Objective To study the effect mechanism of NT on CVS following experimental dog SAH.Methods The measure of NT in plasma and CSF was used by radio immunological analysis.Results The levels of NT in plasma and CSF in groups of injecting blood increased more than that in groups of preinjecting blood and control(P<0.01).After injecting blood 30 min,the levels of NT in plasma and CSF began to increase and was the highest at seventh day,after injecting blood.Conclusion NT may be involved in process of CVS following experimental dog SAH.