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Alzheimer病的分子生物学研究进展 被引量：4

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摘要 根据发病年龄和家族聚集性，Ａｌｚｈｅｉｍｅｒ病（ＡＤ）可分为早发性、迟发性家族性ＡＤ（ＦＡＤ）和散发性ＡＤ（ＳＡＤ）。关于ＡＤ的病因及发病机制，至今仍不完全清楚。本文简介肯定与ＡＤ发生有关的４个基因的结构和它们在ＡＤ发病学上的意义。１ＡＰＰ基因与Ａβ...
作者 毕胜 张昱 吴江
机构地区 白求恩医科大学一院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 1998年第4期254-256,共3页 Journal of Apoplexy and Nervous Diseases
关键词 痴呆 早老性痴呆 分子生物学
分类号 R749.16 [医药卫生—神经病学与精神病学] Q7 [生物学—分子生物学]
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  • 2Mathew J, Sleight P, Lonn E, et al. Reduction of cardiovascular risk by regression of electrocardiographic markers of left vertricular hypertrophy by the angiotensin converting enzyme inhibitor ramipril.Circulation, 2001,104(14):1615-1621.
  • 3Rigat B, Hubert C, Alhenc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest,1990, 86(4): 1343-1346.
  • 4Sharma P, Carter ND, Barley J, et al. Polymorphisms in the gene encoding angiotensin 1-converting enzyme and relationship to its post-translational product in cerebral infarction. J Hum Hypertens.,1994,8(8):633-634.
  • 5Sharma P, Carter ND, Barley J, et al. Molecular approach to assessing the genetic risk of cerebral infarction: deletion polymorphism in the gene encoding angiotensin 1-converting enzyme. J Hum Hypertens, 1994, 8(8): 645-648.
  • 6Villard E, Tiret L, Visvikis S, et al. Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet, 1996, 58(6): 1268-1
  • 7Kreutz R, Hubner N, Ganten D, et al. Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension. Circulation, 19
  • 8Markus HS, Barley J, Lunt R, et al. Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma. Stroke, 1995, 26(8): 1329-1333.
  • 9Erdos EG, Skidgel RA. The angiotensin I-converting enzyme. Lab Invest, 1987, 56(4): 345-348.
  • 10Costerousse O, Allegrini J, Lopez M, et al. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J, 1993, 290 (pt 1):33-40.

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中风与神经疾病杂志
1998年 第4期

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