新抗肿瘤抗生素云南霉素 Ⅲ.抗肿瘤作用

Yunnanmycin, a novel antitumor antibioticⅢ. Antitumor activity

云南霉素是由链霉菌产生的新抗肿瘤抗生素。云南霉素体外试验对肿瘤细胞有杀伤作用。动物体内试验，对小鼠肝癌２２、结肠癌２６以及肉瘤１８０均有显著疗效。使用可耐受剂量，云南霉素１２０ｍｇ／ｋｇ，ｐｏ，×２，对肝癌２２的抑制率达８３％；３０ｍｇ／ｋｇ，ｉｖ，×３，对肝癌２２的抑制率为７７％。

Yunnanmycin, a novel cytosine nucleoside antibiotic produced by a Streptomyces strain which was isolated from a soil sample collected in Yunnan Province, China, showed antitumor activity in vitro and in vivo. By clonogenic assay, yunnanmycin displayed cytotoxicity to KB cells and hepatoma BEL7402 cells with IC50values of 9 and 5μg/ml, respectively. Yunnanmycin markedly suppressed the growth of murine transplantable tumors including hepatoma 22, colon carcinoma 26 and sarcoma 180. At tolerable doses, yunnanmycin (120mg/kg, po, ×2) inhibited the growth of hepatoma 22 and sarcoma 180 by 83% and 72%, respectively. Yunnanmycin, 30mg/kg, iv, ×3, inhibited the growth of hepatoma 22 by 77%. Results indicate that yunnanmycin is highly effective against experimental tumors.