三磷酸腺苷结合盒转运体A1与动脉粥样硬化相关性的研究

Rresearch of Relativity Between ATP-binding Cassette Transporter A1 and Atherosclerosis

由于三磷酸腺苷结合盒转运体A1(ABCA1)在胆固醇逆向转运、胆固醇代谢以及高密度脂蛋白(HDL)代谢过程中起着极其重要的调节作用,因此ABCA1与心血管疾病的发生发展有着密切的关系。ABCA1的发现为脂代谢和动脉粥样硬化(AS)的研究提供了新的思路,如能根据机体脂代谢的需要来调节ABCA1的表达水平,无疑将使AS的治疗达到一个新的高度。通过对近5年文献的查阅和综合,表明ABCA1是与动脉粥样硬化密切相关的重要基因。深入讨论其作用机理,对动脉粥样硬化的防治有重要意义。

As ATP- binding cassette transporter A1 （ABCA1） plays an important role in the course of reverse cholesterol transport, cholesterol metabolism and HDL metabolism, it can be said that ABCA1 is closely related to the cardiovastdar disease. Since the finding of ABCA1, it has provided more ideas to the research of lipid metabolism and atherosclerosis（AS）. If the ABCA1 expression level can be regulated according to the lipid metabolism, the efficacy in treatments of AS will be promoted to a new level. Reviewing the articles from the past 5 years, we can conclude that ABCAI is the critical gene related to AS. It is necessary for us to research its mechanism more deeply for the prevention of AS.