甲磺酸左氟沙星对小鼠全身感染的保护效果的研究

Protecting effect of levofloxacin mesylate onsystemic infections in mice

金葡球菌、大肠埃希氏菌和铜绿假单胞菌各２株分别感染小鼠，甲磺酸左氟沙星口服给药，以评价其体内保护作用。甲磺酸左氟沙星对２株金葡球菌感染小鼠的ＥＤ５０分别为５．２３和７．０４ｍｇ／ｋｇ，对２株大肠埃希氏菌感染小鼠的ＥＤ５０分别为０．４２和０．９５ｍｇ／ｋｇ，对２株铜绿假单胞菌感染小鼠的ＥＤ５０分别为１７．８和２２．４ｍｇ／ｋｇ。甲磺酸左氟沙星对小鼠全身感染的保护作用与对照药左氟沙星游离碱相似，而优于或相当于氧氟沙星和环丙沙星。

Mice were systemically infected by each two strains of S.aureus, E.coli and P.aeruginosa respectively. Then they were orally administered with levofloxacin mesylate (MSALVFX). ED_(50)of MSALVFX on each two strains of S.aureus, E.coli and P.aeruginosa were 5.23∶7.04, 0.42∶0.95 and 17.8∶22.4 mg/kg respectively. Results were similar to levofloxacin free base (as control), but better than or least similar to ofloxacin and ciprofloxacin.