银杏叶提取物对脑干听觉诱发电位的影响

The influence of Ginkgo biloba extracts on brainstem auditory evoked potential

目的：从电生理学角度探讨银杏叶提取物（ＧＢＥ）对缺血性神经细胞的保护作用。方法：采用脑干听觉诱发电位（ＢＡＥＰ）检测６０名椎基底动脉供血不足（ＶＢＩ）患者口服ＧＢＥ前后各波潜伏期、峰间潜伏期及双耳差值的变化。结果：服药后患者ＢＡＥＰ各波潜伏期、峰间潜伏期均逐渐恢复至基本正常水平。双耳差值亦同时逐渐减小，接近正常范围。结论：（１）ＢＡＥＰ是ＶＢＩ的辅助诊断、动态观察和判断预后的可靠指标；（２）双耳差值是最敏感的指标，差值越大，脑干损害的程度越大；

Objective: To explore the protective effect of Ginkgo biloba L. extract on ischemic neuronal cells by electrophysiological method. Methods: The latent period of brainstem auditory evoked potential (BAEP) waves Ⅰ～Ⅲ, Ⅲ～Ⅴ, Ⅰ～Ⅴ, interpeak latency (IPL) and biauricular disparity were observed in 60 patients with vertebrobasilar insufficiency (VBI) before and after administration of Ginkgo biloba extract (GBE). Results: The latent period of all BAEP waves, IPL gradually returned to normal after treatment of GBE, and biauricular disparity was also reduced to normal. Conclusion: (1) BAEP is a reliable index for supplementary diagnosis, dynamic observation and judgement of prognosis of VBI; (2) The biauricular disparity is one of the most sensitive indices mentioned above. The more severe the injury to brainstem is, the greater the biauricular disparity is; (3) GBE has a truly protective effect on ischemic nerve cells.