缺血再灌注中中性粒细胞的呼吸爆发与组织氧化损伤关系研究现状
被引量：1
摘要
1955年Sewell发现，结扎狗冠状动脉一段时间后，恢复血流，实验动物因严重室颤而死；1967年，Bulkley与Hutchins发现冠状动脉搭桥后的病人常发生心肌细胞反常性坏死；1981年Greenberg证实，猫小肠缺血3小时后再恢复血流，粘膜损伤严重。由此可见，缺血组织在恢复血流时常伴随着严重的损伤，这种损伤往往同中性粒细胞呼吸爆发所导致的氧化损伤密切相关。现在一般将缺血／再灌注性损伤定义为：缺血的组织、器官经恢复血液灌注后不但不能使其正常功能和结构恢复，反而加重其功能障碍和结构损伤的现象。
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2009年第5期603-607,共5页
Chinese Journal of Sports Medicine
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