门静脉高压性肠病的研究现状

Advances in research on portal hypertensive enteropathy

肝硬化门静脉高压性肠病(portal hypertensive enteropathy,PHE)的2大主要发病机制是肝内门脉血流阻力增加和流经门脉血流增多.PHE的基本特征是组织病理学上的特征性血管病变.临床表现无特异性,但却是下消化道出血的主要原因.目前为止,PHE的诊断和分级尚无统一标准,治疗上也仅限于小样本经验总结,因此,关于PHE的进一步研究非常必要.本文就PHE的研究现状作一综述.

Portal hypertensive enteropathy, whose fundamental pathologic change is a vasculopathy characterized histopathologically by mucosal and submucosal vessel dilatation, oedema and congestion, mainly results from a combination of increased intrahepatic vascular resistance and increased blood flow through the portal venous system. Though portal hypertensive enteropathy usually has non-specific clinical manifestations, it is a major cause of lower gastrointestinal bleeding. Up to now, there has been no standard for the diagnosis and grading of portal hypertensive enteropathy. Unfortunately, the experience of treatment for portal hypertensive enteropathy only comes from some small-sample trials. For these reasons, an in-depth study of portal hypertensive enteropathy is still necessary. In this article, we will review the advances in research on portal hypertensive enteropathy.