埃索美拉唑的临床应用新进展

Advances in the clinical applications of esomeprazole

质子泵抑制剂(proton pump inhibitors,PPI)在治疗消化系诸多酸相关疾病方面取得了满意的效果,其家族中的第1个单一光学异构体-埃索美拉唑(esomeprazole),应用于临床的7年间,以其相对独特的代谢途径(较其他PPI),高效持久的抑酸效果,较好的安全性和较低的不良反应发生率,得到临床的广泛应用和人们越来越多的关注.本文就近几年国内外对该药主要临床应用研究作一综述.

Esomeprazole is the first proton pump inhibitor （PPI） to be developed as a single optical isomer. Ever since its first clinical application seven years ago, esomeprazole has attracted more and more attention due to relatively unique metabolism （compared to other PPIs）, efficient and durable acid control, better safety and lower incidence of adverse reactions. In this article, we will review the clinical applications of esomeprazole in the treatment of gastroesophageal reflux disease （GERD）, Helicobacter pylori infection, peptic ulcers, NSAID-related gastrointestinal disorders and upper gastrointestinal bleeding.