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软骨细胞凋亡与PI3K/Akt途径及相关信号分子的研究进展 被引量:9

Research progress of chondrocyte apoptosis and PI3K/Akt pathway with related signaling molecules
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作者 余跃伟 夏春
出处 《临床骨科杂志》 2009年第4期457-460,共4页 Journal of Clinical Orthopaedics
关键词 软骨 细胞凋亡 PI3K/AKT 信号传导 cartilage apoptosis PI3 K/Akt signal transduction
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  • 2Wong M L, Kaye A H, Hoveus C M. Targeting malignant glioma survival signalling to improve clinical outcomes [ J ]. Clin Neurosci ,2007,14 (4) :301 - 308.
  • 3Zhao L,Vogt P K. Class Ⅰ PI3K in oncogenic cellular transformation [ J ]. Oncogene,2008,27 (41) :5486 - 5496,.
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  • 7Takeuchi R, Ryo A, Komitsu N, et al. Lowintensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures:a basic science study[ J]. Arthritis Res Ther,2008, 10(4) :77.
  • 8Priore R, Dailey L, Basilico C. Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes [ J ]. Cell Physiol, 2006,207 ( 3 ) : 800 - 808.
  • 9Jin E J,Park K S,Bang O S,et al. Akt signaling regulates actin organization via modulation of MMP-2 activity during chondrogenesis of chick wing limb bud mesenchymal cells [ J ]. Cell Biochem, 2007,102 ( 1 ) :252 - 261.
  • 10Ulici V, Hoenselaar K D, Gillespie J R, et al. The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation [ J ]. BMC Dev Biol,2008,40 (8): 1471 - 1486.

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