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线粒体DNA与双相障碍发病的相关性研究 被引量：7

Research progress of relationship between mitochondrial DNA and bipolar disorder
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摘要 线粒体是细胞能量代谢的中心。人体内线粒体DNA突变可导致细胞氧化磷酸化及能量供应异常,可能与双相障碍的发生有关。文章就线粒体DNA与双相障碍发生的相关性研究进行综述。 Mitochondria are essential elements that generate energy in cells. Mutations of human mitochondrial DNA may lead to aberrant oxidative phosphorylation and energy supplement in cells, indicating a possible relationship with bipolar disorder. The research progress on relationship between mitochondrial DNA and bipolar disorder is reviewed in this paper.
作者 张晨 方贻儒
机构地区 上海交通大学医学院精神卫生中心
出处 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2009年第8期994-996,共3页 Journal of Shanghai Jiao tong University:Medical Science
基金 "十五"国家攻关计划(2004BA720A21-02) 国家高技术研究发展计划("八六三"计划)(2006AA02Z430) 上海市科委基金(064119533)~~
关键词 线粒体DNA 双相障碍 突变 mitochondrial DNA bipolar disorder mutation
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献16

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同被引文献70

  • 1Fleischhacker WW,Cetkovich-Bakmas M,De Hert M,et al.Comorbid somatic illnesses in patients with severe mental disorders:clinical,policy,and research challenges[J].J Clin Psychiatry,2008,69(4):514-519.
  • 2Dean OM,van den Buuse M,Bush AI,et al.A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice[J].Curr Med Chem,2009,16(23):2965-2976.
  • 3Berk M,Malhi GS,Hallam K,et al.Early intervention in bipolar disorders:clinical,biochemical and neuroimaging imperatives[J].J Affect Disord,2009,114(1-3):1-13.
  • 4Steckert AV,Valvassori SS,Moretti M,et al.Role of oxidative stress in the pathophysiology of bipolar disorder[J].Neurochem Res,2010,35(9):1295-1301.
  • 5Valvassori SS,Moretti M,Kauer-Sant'Anna M,et al.Effects of a gastrin-releasing peptide receptor antagonist on D-amphetamine-induced oxidative stress in the rat brain[J].J Neural Transm,2010,117(3):309-316.
  • 6Alsuwaidan MT,Kucyi A,Law CW,et al.Exercise and bipolar disorder:a review of neurobiological mediators[J].Neuromolecular Med,2009,11(4):328-336.
  • 7Andreazza AC,Kauer-Sant'anna M,Frey BN,et al.Oxidative stress markers in bipolar disorder:a meta-analysis[J].J Affect Disord,2008,111(2-3):135-144.
  • 8Kunz M,Gama CS,Andreazza AC,et al.Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(7):1677-1681.
  • 9Valvassori SS,Moretti M,Kauer-Sant'Anna M,et al.Effects of a gastrin-releasing peptide receptor antagonist on D-amphetamine-induced oxidative stress in the rat brain[J].J Neural Transm,2010,117(3)309-316.
  • 10Andreazza AC,Kapczinski F,Kauer-Sant'Anna M,et al.3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder[J].J Psychiatry Neurosci,2009,34(4):263-271.

引证文献7

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上海交通大学学报（医学版）
2009年 第8期

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