帕金森病患者睡眠障碍发病机制的研究

Study on mechanism of sleep disorders associated with Parkinson's disease

帕金森病患者常合并多种睡眠结构的紊乱,主要是睡眠的启动和维持困难、睡眠行为障碍和白天嗜睡。帕金森病引起睡眠结构紊乱的机制目前尚不清楚,可能与多个解剖结构包括脑干、中缝核、孤束核、蓝斑核、丘脑等病变及神经递质包括多巴胺、下丘脑泌素/进食素和褪黑素等改变有关。文章对帕金森病患者睡眠障碍发病机制的研究作一综述。

Sleep disorders are commonly occurred among patients with Parkinson＇s disease, such as difficulties in the initiation of sleep, fragmented sleep, sleep behavior disorder and excessive daytime sleepiness. The mechanism of sleep disorders associated with Parkinson＇s disease is not clear, which may be associated with the injury of brain stem, nuclei of median raphe, nuclei fascieuli solitarii, thalamencephalon and the changes of neurotransmitters as dopamine, hypocretin （orexin） and melatonin. This article gives an overview of the mechanism of sleep disorders associated with Parkinson＇s disease.