美敏伪麻溶液治疗儿童慢性副鼻窦炎有效性和安全性观察

Observation on the efficacy and safety of Robitussin in the treatment of pediatric chronic sinusitis

目的:探讨美敏伪麻溶液治疗儿童慢性鼻窦炎的有效性和安全性。方法:68例慢性副鼻窦炎患儿随机分为治疗组、对照组,2组均给予阿莫西林/克拉维酸钾分散片、标准桃金娘油肠溶胶囊口服、布地奈德鼻喷雾剂喷鼻。治疗组口服儿童美敏伪麻溶液,对照组口服鼻窦炎口服液,均连服7d后观察2组患儿咳嗽、流涕、鼻塞、清嗓、头痛等症状缓解情况,体征主要是观察鼻窦邻近组织的红、肿、压痛及鼻涕倒流入咽部,中鼻道有无脓液。同时观察不良反应发生情况。结果:治疗组的临床疗效较对照组有显著改善(P<0.01);不良反应发生率分别为4.41%,5.58%,治疗组与对照组比较差异无显著性(P>0.05)。结论:美敏伪麻治疗儿童慢性副鼻窦炎的临床疗效肯定,早期缓解症状,改善患儿生活质量,安全性佳。

OBJECTIVE To investigate the efficacy and safety of Robitussin in the treatment of the pediatric patients with chronic sinusitis. METHODS A total of 68 pediatric patients with chronic sinusitis were randomly divided into 2 groups. All cases were treated with amoxicillin and clavulanate potassium dispersible tablets, myrtol standardized enteric coated soft capsules, and budesonide nasal spray. The treatment group was treated with Robitussin. While the control group was treated with Bidouyan oral solution. The clinical therapeutic effect and ADRs of two groups were observed after treatment for 1 week. RESULTS Outstanding clinical therapeutic effect was found in the treatment group as compared with the control groups. The effective rate of the treatment group was 85.29%, while the control group was 52. 94% respectively （P〈0. 01）. There were no obvious ADRs in 2 groups,the rates of ADRs in treatment group was 4. 41% ,the rates of control group was 5.58% respectively （P〉 0. 05）. CONCLUSION The clinical therapeutic effect of Robitussin on the treatment of pediatric chronic sinusitis is better than that of control group. The safety of Robitussin is eouivalent to Bidouyan oral solution.