泮托拉唑粉针治疗消化性溃疡出血的疗效观察

Treatment observation of pantoprazole effect on peptic ulcer hemorrhage

目的:评价泮托拉唑(韦迪粉针)对消化性溃疡出血的疗效。方法:选择消化性溃疡出血患者46例,随机分为2组,韦迪治疗组24例,奥美拉唑对照组22例,分别用韦迪或奥美拉唑40mg溶于100mL生理盐水静脉滴注,bid,疗程5d。观察出血情况改变。结果:治疗组与对照组的显效率分别为75%与63.64%,有效率分别为20.83%与31.82%,总有效率分别为95.83%与95.45%,2组总有效率比较差异无显著性(P>0.05)。结论:韦迪是治疗消化性溃疡出血安全、有效的药物。

OBJECTIVE To evaluate the effect of pantoprazole（Weidi） on peptic ulcer hemorrhage. METHODS The 46 patients with peptic ulcer hemorrhage were randomly assigned to two groups, and 24 patients for Weidi pantoprazole group and 22 patients for omeprazole control group. 40 mg of Weidi pantoprazole and omeprazole respectively dissolved with 100 mL pharmacy physiological saline for intravenous dripping. 2 times a day and the treatment period was 5 days to observe the changes of the hemorrhage. RESULTS The obvious efficient rates of Weidi patients and omeprazole patients were 75 % and 63. 64%, respectively; and effective rates reached 20. 83% and 31.82, respectively; general effective rates achieved 95.83% and 95.45% of Weidi patients and omeprazole patients, and there was no significant difference between these two groups （P〈0. 05）. CONCLUSION Weidi pantoprazole is a kind of safe and effective medicament to treat peptic ulcer hemorrhage.