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β淀粉样蛋白对线粒体作用的研究进展 被引量：2

Advances in understanding the effect of amyloid-β on mitochondrial
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摘要 阿尔茨海默病的一个重要病理特征是胞外β淀粉样蛋白沉积形成的老年斑,β淀粉样蛋白可以引起氧化损伤以及神经细胞凋亡等。随着研究的深入,在细胞内也发现了β淀粉样蛋白的存在。线粒体是细胞内ATP和活性氧自由基产生的主要部位,在氧化损伤和细胞凋亡过程中起到重要的作用。近年的研究表明,β淀粉样蛋白对线粒体有很重要的作用。该文主要针对这一领域的进展,介绍了阿尔茨海默病中β淀粉样蛋白对线粒体多个生理过程的作用以及这些作用在阿尔茨海默病中产生的影响。 Alzheimer＇s disease （AD） is characterized by the impairment of cognitive functions and changes in behavior and personality. Mitochondrial oxidative damage and synaptic pathology have recently been reported as early events in AD progression. Increasing evidence suggests that amyloid-β might be the causal factor of mitochondrial oxidative damage and synaptic pathology in AD and the effect of amyloid-β on mitochondrial might be an upstream event in the pathogenesis of AD. In this review we made a summary of the effect of amyloid-β on mitochondrial in Alzheimer＇s disease.
作者 陈林 黄汉昌 姜招峰
机构地区 首都师范大学生命科学学院 北京联合大学应用文理学院
出处 《生命科学》 CSCD 北大核心 2009年第4期504-507,共4页 Chinese Bulletin of Life Sciences
基金 北京市属高等学校人才强教计划资助项目(PHR20090513)
关键词 Β淀粉样蛋白 线粒体 阿尔茨海默病 amyloid-β mitochondrial Alzheimer＇s disease
分类号 Q51 [生物学—生物化学] R749.1 [医药卫生—神经病学与精神病学]
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参考文献21

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同被引文献30

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生命科学
2009年 第4期

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