神经肽Y及其受体Y_1、Y_2对痛觉调制的研究进展

Neuropeptide Y and its receptors Y_1,Y_2 modulation of pain

神经肽Y(neuropeptide Y,NPY)是一种由36个氨基酸残基组成的肽类激素,属胰多肽家族,广泛分布于中枢及外周神经组织的神经元中。NPY主要参与摄食行为、心血管活动、垂体分泌等生理功能的调节。NPY还参与了痛觉调制。NPY受体有Y1、Y2、Y3、Y4、Y5和Y6六种亚型。目前对Y1受体和Y2受体的研究较多,显示Y1受体和Y2受体参与痛觉调制。但现在对NPY在痛觉中的具体作用机制还不清楚。该文对NPY及其Y1受体、Y2受体在痛觉调制中的作用作一概述。

Neuropeptide Y, a peptide hormone with residues of 36 amino acids, belongs to pancreatic polypeptide family. This peptide is widely distributed in the central and peripheral nerve systems. NPY is mainly involved in feeding behavior, cardiovascular activity, pituitary secretion, etc. It is found in recent years that NPY is also involved in pain modulation. There are six NPY receptor subtypes, Y1, Y2, Y3, Y4, Y5 and Y6. Currently, Y1 and Y2 receptors have attracted attentions. The studies have shown that Y1 and Y2 receptors are associated with pain modulation or processing. However, their mechanisms are not clear. This review outlines the recent studies about functional role of NPY in pain modulation.