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干细胞源胰岛素分泌细胞中胰岛素原转化障碍的原因及对策 被引量：1

The obstacles in the conversion of proinsulin to insulin in stem cell-derived insulin-producing cells
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摘要 近年来,诱导干细胞向功能性胰岛素分泌细胞分化已取得了较大进展,但不论何种干细胞来源,采取何种诱导方案,诱导的胰岛素分泌细胞均不同程度地存在着胰岛素原向胰岛素转化的障碍,严重影响了其治疗糖尿病的效果。该文从胰岛素合成和分泌的生理学角度探讨胰岛素分泌细胞不成熟的原因及机制,从而指出目前在干细胞向胰岛素分泌细胞诱导过程中存在的不足并提出相应的解决办法。 Progress has been made in inducing stem cells to differentiate towards functional insulin-producing cells （IPCs） in recent years. Despite the sources of the stem cells and the protocols used for induction, there are still difficulties in the conversion of proinsulin to insulin in the stem cell-derived IPCs, which hamper the IPCs＇ effects on diabetes therapy, This review discusses the possible causes and the underlying mechanisms from the physiological viewpoints of insulin synthesis and secretion, and points out the limitations and solutions in the course of inducing stem ceils towards IPCs.
作者 王跃春 段阿林 李佳穗 张洹
机构地区 暨南大学医学院生理教研室 暨南大学医学院血液病研究所
出处 《生命科学》 CSCD 北大核心 2009年第4期536-541,共6页 Chinese Bulletin of Life Sciences
基金 广东省医学科研基金资助项目(2008350) 国务院侨办重点学科建设基金资助项目(2005) 暨南大学2008年"挑战杯"大学生课外学术科技创新活动研究项目 2009年广东省自然科学基金博士科研启动项目(9451063201002957)
关键词 干细胞 胰岛素分泌细胞 胰岛素原 胰岛素 stem cells insulin-producing cells proinsulin insulin
分类号 Q813 [生物学—生物工程] R587.1 [医药卫生—内分泌]
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参考文献22

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二级参考文献10

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共引文献9

同被引文献17

  • 1葛圣雷,陈主初,肖志强,谢鼎华.分泌性蛋白质的研究策略[J].生命的化学,2005,25(6):476-477. 被引量：6
  • 2张海婧,刘辉,吕丽艳,陈国强,李智立.分泌蛋白质组研究进展[J].分析化学,2007,35(6):912-918. 被引量：7
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生命科学
2009年 第4期

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