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aac(6')-Ib-cr介导的喹喏酮类新耐药机制研究进展 被引量：5

Research on the new resistance mechanism of quinolones mediated by aac(6')-Ib-cr
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摘要 AAC(6')-Ib是重要的氨基糖苷乙酰基团转移酶,其变异基因aac(6')-Ib-cr可同时作用于氨基糖苷类和氟喹诺酮类两类结构不同的抗生素,是引起细菌耐药性的一种重要作用机制。该文主要对aac(6')-Ib-cr介导的喹诺酮类新耐药机制相关研究进行综述。 AAC（6＇）- Ib are important aminoglycoside acetyltransferases.The variable gene aac（6＇）-Ib-cr acts on both quinolones and aminoglycosides, which belong to different classes of antibiotics based on their chemical structures, leading to the bacteria resistance. This paper briefly reviews the new resisitant mechanism of quinolones mediated by aac（6＇）-Ib-cr.
作者 孙攀 殷瑜 陈代杰
机构地区 上海师范大学生命与环境科学学院 上海来益生物药物研究开发中心 上海医药工业研究院
出处 《生命科学》 CSCD 北大核心 2009年第4期584-588,共5页 Chinese Bulletin of Life Sciences
基金 国家科技基础条件平台建设项目(2005DKA21203)
关键词 细菌耐药性 aac(6')-Ib-cr 喹诺酮类 氨基糖苷类 bacteria resistance aac（6＇）-Ib-cr quinolones aminoglycosides
分类号 Q555 [生物学—生物化学] R978.1 [医药卫生—药品]
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参考文献26

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  • 6Jacoby GA, Walsh KE, Mills DM, et al. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother, 2006, 50(4): 1178-82.
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同被引文献56

  • 1Martinez-Martinez L,Pascual A,Jacoby GA.Quinolone resistance from a transferable plasmid.Lancet,1998,351(9105):797-799.
  • 2Hata M,Suzuki M,Matsumoto M,et al.Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.Antimicrob Agents Chemother,2005,49(2):801-803.
  • 3Jacoby GA,Walsh KE,Mills DM,et al.qnrB,Another Plasmid-Mediated Gene for Quinolone Resistance.Antimicrob Agents Chemother,2006,50(4):1178-1182.
  • 4Robicsek A,Strahilevitz J,Jacoby GA,et al.Fluoroquinolone modifying enzyme:a novel adaptation of a common aminoglycoside acetyltransferase.Nat Med,2006,12(1):83-88.
  • 5Yamane K,Wachino JI,Suzuki S,et al.New plasmid-mediated fluoroquinolone efflux pump,QepA,found in an Escherichia coli clinical isolate.Antimicrob Agents Chemother,2007,51(9):3354-3360.
  • 6Cavaco LM,Hasman H,Xia S,et al.qnrD,a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin.Antimicrob Agents Chemother,2009,53(2):603-608.
  • 7Wang M,Guo Q,Xu X,et al.New plasmid-mediated quinolone resistance gene,qnrC,found in a clinical isolate of proteus mirabilis.Antimicrob Agents Chemother,2009,53(5):1892-1897.
  • 8Wang M,Tran JH,Jacoby GA,et al.Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai,China.Antimicrob Agents Chemother,2003,47(7):2242-2248.
  • 9Warburg G,Korem M,Robicsek A,et al.Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005.Antimicrob Agents Chemother,2009,53(3):1268-70.
  • 10Park CH,Robicsek A,Jacoby GA,et al.Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme.Antimicrob Agents Chemother,2006,50(11):3953-3955.

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生命科学
2009年 第4期

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