藏药臭蚤草的一个新的苯丙素苷类成分(英文)

A New Phenylpropanoid Glycoside from Tibetan Folk Drug Pulicaria insignis

为了研究藏药臭蚤草的活性成分,我们利用各种柱色谱技术,从藏药臭蚤草甲醇提取物的乙酸乙酯萃取相分离到4个化合物,通过1D、2DNMR、MS和HRMS等试验,鉴定为2,4-dihydroxy-6-methyl-ethanone-4-O-β-D-Glc(1),4-(3′-hydroxypropyl)-2,6-dimethoxyphenol-3′-O-β-D-glcoside(2),4-allyl-2-methoxyphenol-1-O-β-D-glco-side(3),2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6′-O-Ac)-α-L-Rha-(1→2)-β-D-Glc(4),其中化合物1～3为苯丙素苷类化合物,化合物4为蒽醌苷。化合物1～4都是首次从该属植物中分离得到,化合物1为新的苯丙素苷类化合物。

In order to investigate the bioactivity constituents of Tibetan folk drug Pulicaria insignis, four compounds were isolated with chromatography techniques. Structures were elucidated to be 2,4-dihydroxy-6-methyl-ethanone-4-O-β-D- Glc （ 1 ）, 4-＇（ 3＇-hydroxypropyl ） -2,6-dimethoxyphenol-3 ＇-O-β-D-glcoside （ 2 ）, 4 -allyl-2 -methoxyphenol- 1 -O-β-D-glcoside （ 3 ）, 2-methyl- 1,3,6 -trihydroxy-9, 10 -anthraquinone-3-O- （ 6＇-O-Ac ） -α-L-Rha- （ 1 →2 ） -E-D-Glc （ 4 ） on the basis of spectroscopic analysis including 1D,2D-NMR, MS and HRMS. Four compounds were isolated from the genus Pulicaria for the first time. 2,4-Dihydroxy-6-methyl-ethanone-4-O-β-D-Glc（ 1 ）is a new phenylpropanoid glycoside.