滑桃树内生真菌Fusarium sp. 1RGa-1b中萘醌类代谢产物及其抗菌活性研究

Naphthaquinones from Fusarium sp. 1RGa-1b,an Endophytic Fungus Associated with Trewia nudiflora(Euphorbiaceae)

从滑桃树内生真菌Fusarium sp.(1RGa-1b)的发酵代谢产物中分离得到6个一系列的萘醌类色素化合物,通过波谱分析将其结构鉴定为:3-methylether-fusarubin(1),anhydrofusarubin(2),2-acetonyl-3-methyl-5-hydro-gen-7-methoxy-naphthazarin(3),2-acetonyl-3-methyl-7-methoxy-8-hydrogen-naphthazarin(4),2-acetonyl-3-methyl-7-methoxy-naphthazarin(5),2-isopropanol-3-methyl-7-methoxy-naphthazarin(6)。利用纸片扩散法对这些化合物的抗细菌及抗真菌活性进行了初步测试,实验结果表明:化合物3和4具有弱的抗金黄色葡萄球菌的活性。

An isolate of Fusarium sp. 1RGa-1b was obtained from the root of Trewia nudi.flora,a plant of Euphorbiaceae family. The ethyl acetate extraction part of the crude extract from culture of this fungus afforded six naphthaquinones. The structures of these compounds were identified as 3-methy ether-fusarubin（1）, anhydrofusandain（2） ,2-acetunyl-3-metb- yl-5-hydrogen-7-methoxy-naphthazarin （ 3 ）, 2-acetonyl-3-methyl-7-ethoxy-8-hydrogen-naphthazarin （ 4 ）, 2-acetonyl-3- methyl-7-methoxy-naphthazarin（ 5 ）, 2-isopropanol-3-methyl-7-methoxy-naphthazarin （ 6 ）, based on analysis of spectro- scopic data. Antifungal and antibacterial assay tests revealed that 3 and 4 showed in vitro weak antibacterial activity against Staphylococcus aureus.