期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD—TK双自杀基因系统联合染料木黄酮对鼠前列腺癌的治疗作用

原文传递
导出
摘要 CD-TK双自杀基因包含单纯疱疹病毒胸苷激酶（HSV—TK）和大肠杆菌胞嘧啶脱氨酶（CD）基因，能将丙氧鸟苷（GCV）及5-氟胞嘧啶（5-Fe）等无毒的前体药物转化成毒性药物，抑制RNA及DNA合成，从而导致肿瘤细胞的凋亡，研究表明二者协同可以显著增强对肿瘤细胞的杀伤作用。
作者 朱文辉 杜跃军 梁中锟 姜耀东 郑少斌 谭万龙
机构地区 南方医科大学南方医院泌尿外科
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2009年第9期639-640,共2页 Chinese Journal of Urology
基金 广东省自然科学基金资助项目（020059）
关键词 自杀基因系统 CD-TK 染料木黄酮 治疗作用 前列腺癌 单纯疱疹病毒胸苷激酶 胞嘧啶脱氨酶 5-氟胞嘧啶
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

  • 1谭万龙,谢毅,吴元东,朱文辉,郑少斌.腺病毒介导融合双自杀基因治疗膀胱癌[J].南方医科大学学报,2006,26(5):594-597. 被引量：13
  • 2Brehmer M. Morphological changes in prostatic adenomas after transurethral microwave thermotherapy. Br J Urol, 1997, 80: 123-127.
  • 3Candy T. Clinical effects of phytoestrogens. Philadelphia: Lippincott Williams&Wilkins Inc, 2001:836- 842.
  • 4Pinski J, Wanq Q, Quek ML, et al Genistein-induced neuroendocrine dif ferentiation of prostate cancer cells Prostate, 2006, 66:1136-1148.
  • 5Katdare M, Osborne M, Telang NT. Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER -2/ neu oncogene expressing human breast epithelial cells. Int J Oncol, 2002, 21: 809-815.
  • 6Pan B, Yao KS, Monia BP, et al. Reversal of cisplatin resistance in human ovarian cancer cell lines by a c2jun antioligocleoxynu cleotide ( ISIS 10582): evidence for the role of tran scription factor overexpression in etermining resistant phenotype. Biochem Pharmacol, 2002, 63: 1699-1707.
  • 7Wang Y, Raffoul JJ, Che M. Prostate treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model. Radiat Res, 2006, 166: 73-90.
  • 8Banerjee PP, Banerjee S, Brown TR. Bcl-2 protein expression correlates with cell survival and androgen independence in rat prostatic lobes. Endocrinology, 2002, 143: 1825-1832.

二级参考文献14

  • 1林荣凯,黄宗海,苏国强,柯志勇,陈建雄,周俊杰.血管内皮生长因子受体启动子驱动重组腺病毒双自杀基因系统选择性杀伤大肠癌细胞[J].第一军医大学学报,2005,25(5):524-527. 被引量：5
  • 2Cheon J, Moon du G, Cho HY, et al. Adenovirus-mediated suicide-gene therapy in an orthotopic murine bladder tumor model[J]. Int J Urol, 2002,9:261-7.
  • 3Edelman MJ. New approaches to treatment of metastatic bladder cancer[J]. Curr Oncol Rep, 2000, 2: 379-85.
  • 4Sutton MA, Freund CT, Berkman SA, et al. In vivo adenovirusmediated suicide gene therapy of orthotopic bladder cancer [J]. Mol Ther, 2000, 2:211-7.
  • 5Freund CT, Sutton MA, Dang T, et al. Adenovirus-mediated combination suicide and cytokine gene therapy for bladder cancer[J]. Anticancer Res, 2000, 20: 1359-65.
  • 6Sutton MA, Berkman SA, Chen SH, et al. Adenovirus-mediated suicide gene therapy for experimental bladder cancer [J]. Urology,1997, 49: 173-80.
  • 7Zhang Z, Shirakawa T, Hinata N, et al. Combination with CD/5-FC gene therapy enhances killing of human bladder-cancer cells by radiation [J]. J Gone Med, 2003, 5: 860-7.
  • 8Okada T, Caplen NJ, Ramsey WJ, et al. In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivoIJ]. J Gene Med, 2004, 6: 288-99.
  • 9Xu G, McLeod HL. Strategies for enzyme/prodrug cancer therapy[J]. Clin Cancer Res, 2001, 7:3314-24.
  • 10Lee Y J, Lee H, Borrelli MJ. Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: Hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity [J]. Cancer Gene Ther, 2002, 9: 267-74.

共引文献12

中华泌尿外科杂志
2009年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部