1Lipi R,Dotta F, Marsell L,et al. Prolonged exposure to free fatty acid has cytostatic and pro -apoptotic effects on human pancreatic islets[ J]. Diabetes ,2002,51 (5) : 1437 - 1443.
6Lalloyer F, Vandewalle B, Pereevault F, et al. Peroxisome proliferator - activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets[J~. Diabetes, 2006, 55(6): 1605- 1613.
7Hampson P, Chahal H, Khanim F, et al. PEP005, a selective small moleccule activation of protein kinase C, has potent anti-leukemic activity via the delta isoform of PKC[J]. Blood, 2005, 106(4) :1362 - 1368.
9Rhodes CJ. Type 2 diabetes - amatter of beta - cell life and death [ J ]. Science ,2005,307 ( 5708 ) :380 - 384.
10Greene MW, Murices N, Garofalo RS, et al . Modulation of human insulin receptor substrate - 1 tyrosine phosphorylation by protein kinase cdelta[J]. Biochem, 2004, 378(Pt 1): 105- 116.
4Shimabukruo M, Ohneda M, lee Y, et al. Role of nitric oxide in obesity- induced beta cell disease[J]. J Clin Invest, 1997, 100(2) :290 - 295.
5Mixunmo N, Yoshitomi H, Ishida H, et al. Altered bcl - 2 and bax expression and intracellular Ca^2+ signaling in apoptosis of pancreatic cells and the impairment of glucose - induced insulin secretion[J]. Endocrinology, 1998,139(3) : 1429 - 1439.
6Rabinovitch A, Suarez- Pinzon W, strynadka K, et al. Transfecfion of human pancreatic islets with an anti - apoptotic gene(bcl -2) protects beta- cells from cytosine- induced destruction[ J ].Diabetes, 1999,48(6) : 1223 - 1229.
7White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab, 2002,283: E413-E422.
8Roper MG, Qian WJ, Zhang BB, et al. Effect of the insulin mimetic L-783,281 on intracellular [Ca2+ ] and insulin secretion from pancreatic β-cells. Diabetes, 2002,51: S43-S49.
9Aspinwall CA, Qian WJ, Roper MG, et al. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2 + stores in insulin-stimulated insulin secretion in β-cells. J Biol Chem, 2000,275: 22331-22338.
10Leibigier B, Liebigier IB, Moede T, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell,2001,7:559-570.