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脂毒性促进胰岛β细胞凋亡在2型糖尿病中的作用 被引量:3

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作者 陆亚群 苏珂
出处 《上海医药》 CAS 2009年第9期399-401,共3页 Shanghai Medical & Pharmaceutical Journal
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参考文献16

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  • 6Lalloyer F, Vandewalle B, Pereevault F, et al. Peroxisome proliferator - activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets[J~. Diabetes, 2006, 55(6): 1605- 1613.
  • 7Hampson P, Chahal H, Khanim F, et al. PEP005, a selective small moleccule activation of protein kinase C, has potent anti-leukemic activity via the delta isoform of PKC[J]. Blood, 2005, 106(4) :1362 - 1368.
  • 8张研,袁莉.β细胞胰岛素受体信号系统与β细胞功能[J].国外医学(内分泌学分册),2005,25(4):259-261. 被引量:6
  • 9Rhodes CJ. Type 2 diabetes - amatter of beta - cell life and death [ J ]. Science ,2005,307 ( 5708 ) :380 - 384.
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二级参考文献31

  • 1陈艳平,曹德权,常业恬.一氧化氮在全肝缺血再灌注大鼠肺损伤中的作用[J].中国医学工程,2006,14(3):254-256. 被引量:2
  • 2高洪伟,洪天配,李琼芳.烟酰胺对白细胞介素1β所致胰岛损伤的防护作用及其机制[J].中华医学杂志,1996,76(7):497-500. 被引量:7
  • 3归东梅,李迅,王英爽,高殿文.左旋-硝基精氨酸甲脂对急性高眼压状态下大鼠视网膜的影响(英文)[J].中国现代医学杂志,2007,17(6):641-644. 被引量:1
  • 4Shimabukruo M, Ohneda M, lee Y, et al. Role of nitric oxide in obesity- induced beta cell disease[J]. J Clin Invest, 1997, 100(2) :290 - 295.
  • 5Mixunmo N, Yoshitomi H, Ishida H, et al. Altered bcl - 2 and bax expression and intracellular Ca^2+ signaling in apoptosis of pancreatic cells and the impairment of glucose - induced insulin secretion[J]. Endocrinology, 1998,139(3) : 1429 - 1439.
  • 6Rabinovitch A, Suarez- Pinzon W, strynadka K, et al. Transfecfion of human pancreatic islets with an anti - apoptotic gene(bcl -2) protects beta- cells from cytosine- induced destruction[ J ].Diabetes, 1999,48(6) : 1223 - 1229.
  • 7White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab, 2002,283: E413-E422.
  • 8Roper MG, Qian WJ, Zhang BB, et al. Effect of the insulin mimetic L-783,281 on intracellular [Ca2+ ] and insulin secretion from pancreatic β-cells. Diabetes, 2002,51: S43-S49.
  • 9Aspinwall CA, Qian WJ, Roper MG, et al. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2 + stores in insulin-stimulated insulin secretion in β-cells. J Biol Chem, 2000,275: 22331-22338.
  • 10Leibigier B, Liebigier IB, Moede T, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell,2001,7:559-570.

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