2型糖尿病患者肾上腺激素水平及行为类型关系探讨

The relationship of behavior pattern and adrenal hormone in patients with type 2 diabetes

目的 探讨2型糖尿病的发生与肾上腺激素水平及行为类型的关系。方法60例2型糖尿病患者和60例健康自愿者进行A型行为问卷测试，均检测空腹血糖（FPG）、空腹胰岛素（FINS）、去甲肾上腺素（NE）、肾上腺素（E）、餐后2h血糖（2hPPG）及24h尿游离皮质醇（UFC）水平，测身高、体重、计算体重指数（BMI）、胰岛素抵抗指数（HOMA—IR）。结果2型糖尿病组A型行为评分、NE、E、UFC、BMI、HOMA—IR明显高于正常对照组（P〈0．05或P〈0．01），病例组A型行为评分值与NE、E、UFC、FPG,2hPPG呈正相关关系。以HOMA—IR为因变量的回归分析显示，UFC、BMI是进入回归方程的因素。结论A型行为是促发2型糖尿病的重要因素，其机制与肾上腺激素水平变化有关。

Objective To investigate the relationship of behavior pattern and ademal hormone in patients with type 2 diabetes. Methods Sixty patients with type 2 diabetes and 60 normals were involved in the study . They were surveyed by type A behavior pattern （TABP） questionaire. Test fasting plasma glucose （FPG） ,insulin （FINS）, NE, E and 2 h plasma glucose （2 h PPG） ,24 h urinary free cortisol（UFC） ,calculate BMI and HOMA -IR. Results The score of TH ＋ CH and the levels of NE,E, UFC,BMI,HOMA - IR were higher than those of controls（ P 〈0.05 orP 〈0.01 ） ,TH ＋ CH was positively ralated to NE, E, UFC, FPG, 2hPPG. Conclusions Type A Behavior Pattern is an important risk factor to type 2 diabetas, and its mechanisms is the alteration of adrenal hormone.