溃疡性结肠炎治疗前后超声微探头声像图变化分析

Analysis of image changes of ulcerative colitis using miniprobe ultrasound colonoscopy

目的通过溃疡性结肠炎(ulcerative colitis,UC)患者接受柳氮磺胺吡啶治疗前后超声微探头声像图的对比分析,使临床对溃疡性结肠炎诊断、疾病程度及治疗效果判断更正确。方法25例轻中型UC患者接受柳氮磺胺吡啶片6周治疗剂量前后作超声微探头检查并测量直肠或乙状结肠炎症最明显处肠壁最大厚度、平均厚度及第1层、第2层、第3层肠壁厚度进行统计比较分析。结果治疗后超声内镜检测肠壁最大厚度、平均厚度及第1层、第2层、第3层肠壁厚度较治疗前均明显变薄。结论溃疡性结肠炎时肠壁的黏膜层、黏膜下层增厚,尤以黏膜下层明显,柳氮磺胺吡啶治疗效果明显,随着症状改善、内镜图像明显好转,超声微探头复测肠壁厚度也明显变薄。超声内镜将有助于UC的诊断和治疗效果的判断。

[Objective] To assess the diagnosis, severity of ulcerative colitis and treatment effectiveness with mini-probe ultrasound colonoscopy before and after using sulfasalazine tablets clinically. [ Methods] Totally 25 patients suffered from mild and medium ulcerative colitis accepted the treatment with sulfasalazine tablets for 6 weeks. Before and after the treatment, the maximal and average thickness, and the thickness of the first, seeond and third layer of colon and rectum were measured on the loci with most obvious inflammation using mini-probe ultrasound colonoseopy, and then compared statistically. [ Results ] After the treatment, the maximal thickness, average thickness and the thickness of first, second and third layer of colon and rectum were all decreased （P 〈 0.01）. [Conclusions] The patients suffering from ulcerative colitis have thicker colon and rectum wall on mucosa and submucous layer, especial submucous layer. After the treatment with sulfasalazine tablets, the symptoms and the image of colonoscopy will be improved; the thickness of the wall will be decreased detected by mini-probe ultrasound colonoscopy. Mini-probe ultrasound colonoseopy helps for the diagnosis and the treatment effectiveness assessment of ulcerative colitis.