海南省霍乱疫情分离菌株对抗生素敏感性研究

Antibiotic resistance of isolated Cholera strains in Hainan province

目的了解海南省霍乱疫情分离菌株对抗生素的敏感性,为临床治疗和霍乱防治提供科学依据。方法采用WHO推荐的改良K-B纸片法,对2008年海南省霍乱暴发点采集的81株O1群霍乱弧菌进行18种抗生素的敏感性试验。结果全部菌株对诺氟沙星、头孢噻肟、头孢噻吩100%敏感;对链霉素、复方新诺明、多粘菌素B、磺胺异噁唑的耐药率均为100%。四环素的耐药率为92.59%。结论诺氟沙星、头孢噻肟、头孢噻吩可作为今后我省病例和带菌者的治疗指导用药,链霉素、复方新诺明、多粘菌素B、磺胺异噁唑不宜使用。四环素也不宜使用。

Objective To study the antibiotic resistance of Vibrio cholerae in Hainan province,and to provide the references for clinical treatment and prevention and control of cholera. Methods Eighty-one samples from outbreak of cholera epidemic were collected in Hainan province in 2008. The antibiotic susceptibility of the 81 strains to 18 kinds of antibacterial was determined by improved K-B method recommended by WHO. Results All the 81 strains were susceptible to norfloxacin ,cefotaxime and cephalothin. The rate of resistance to streptomycin, sulphamethoxazole/trimethoprim, sulphafurazole and polymyxin B were 100%. The rate of resistance to tetracycline was 92. 59% （75/81）. Conclusion Norfloxacin,cefotaxime and cephalothin could be the choice of clinical treatment for case and carrier of Vibrio cholerae in Hainan province. But streptomycin, sulphamethoxazole/trimethoprim, sulphafurazole, polymyxin B, and tetmcychine could not be used.