左氧氟沙星相关精神障碍

Mental disorder associated with levofloxacin

1例40岁女性因患慢性支气管炎急性发作和阻塞性肺气肿,给予左氧氟沙星0.2 g,2次/d静滴;甘草片4片,3次/d;鲜竹沥液20 ml,3次/d;茶碱缓释片(0.2 g)1片,2次/d治疗。第2天,患者出现行为异常,幻视,幻听。除外肺性脑病和茶碱中毒,考虑精神障碍与左氧氟沙星有关。停用左氧氟沙星,给予抗精神病药物治疗,2 d后患者症状消失。

A 40-year-old woman received an IV infusion of levofloxacin 0.2 g twice daily, 4 glycyrrhyza tablets, Xianzhuli solution 20 ml thrice daily, and 1 theophylline sustained-release 0. 2 g tablet twice daily for acute attack of chronic bronchitis and obstructive emphysema. The next day, the patient developed abnormal behavior, visual hallucination, and auditory hallucination. Pulmonary encephalopathy and theophylline poisoning were excluded, and mental disorder was considered to be levofloxacin-associated. Levofloxacin was stopped and antipsychotics were given. Two days later, her symptoms disappeared.