摘要
设计了用于透皮给药系统（ＴＴＳ）体外释药试验的改良桨碟法，并以两种ＴＴＳ商品——膜控贮库型的硝酸甘油和骨架型的酮洛芬为模型药物，进行了改良桨碟法、桨网法、柱筒法和往复柱筒法等４种体外释药方法的对比试验。结果表明桨网法较好，可以替代美国药典方法。
Improved method for study the in vitro drug release profiles of transdermal delivery/therapeutic system was used to determine the in vitro release of Nitroderm TTS and Morhus Tape.The results were compared with the USP methods:cylinder stirring element and reciprocating holder.It is indicated that the newly developed method is more versatile and even simpler to operate than the USP methods.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第9期393-395,共3页
Chinese Journal of Pharmaceuticals
关键词
透皮给药系统
体外释药
transdermal delivery system,in vitro drug release
