高本底辐射居民机体抗氧化水平研究

Study on antioxygen level in inhabitants of high background radiation area in Yangjiang

目的探讨小剂量慢性长期连续照射人群的抗氧化水平的改变。方法选择我国阳江天然放射性高本底辐射地区(HBRA)的53名50～59岁男性居民作为研究对象,另选择恩平市横坡镇(CA)出生并长大的年龄相仿的男性居民作为对照人群。分别抽取他们周围血5 ml,并测定血清中超氧化物歧化酶(SOD)活力、谷胱甘肽过氧化物酶(GSH-Px)活力、非特异性过氧化氢酶(CAT)活力、总抗氧化能力(T-AOC)的含量。结果在HBRA和CA人群血清中,CAT活力分别为(2.48±2.19)×103、(2.20±1.65)×103U/L,SOD活力分别为(65.93±38.50)×103、(50.23±26.19)×103U/L,GSH-Px活力分别为(28.81±6.36)×103、(23.17±4.33)×103U/L,T-AOC含量分别为(28.81±6.36)×103、(11.41±3.78)×103U/L。与CA组相比,HBRA组人群SOD活力、GSH-Px活力、T-AOC含量较高,差异均有统计学意义(P<0.05),CAT活力略高,但差异无统计学意义(P>0.05)。结论天然放射性高本底辐射(简称高本底辐射)能提高人群抗氧化能力。

Objective To examine antioxygen level in inhabitants living in Yangjiang natural high background radiation area（HBRA）.Methods 53 inhabitants aged from 50 to 59 in HBRA were selected as the exposure group and inhabitants in Enping control area（CA） as the control group.Activities of superoxide dismutase（SOD）,CAT,glutamylcysteinylglycine（GSH-Px） and content of total antioxygen capacity（T-AOC） were determined in serum with chemical colorimetric method.Results In HBRA and CA,activities of CAT,SOD and GSH-Px were（2.48 ±2. 19） ×10^3 and（2.20 ± 1.65） ×10^3 U/L, （65.93 ±38.50） ×10^3 and （50. 23 ±26. 19） ×10^3 U/L, （28. 81 ±6. 36） ×10^3and （23.17 ±4. 33） ×10^3 U/L,eontents of T-AOC were （28. 81 ±6.36） ×10^3 and （ 11.41 ±3.78） ×10^3 U/L,respeetively. Compared to CA,activities of SOD and GSH,eontent of TAOC increased signifieandy in HBRA （ P 〈 0. 05 ）. Activity of CAT inereased to some extent in HBRA but without significant difference （ P 〉 0. 05 ）. Conclusion Chronic exposure to natural high background radiation can increase antioxygen lewd.