核因子-κB、增殖性细胞核抗原在宫颈癌组织中的表达及意义

Expression and significance of nuclear factor-kappa B and proliferating cell nuclear antigen in uterine cervix cancer tissues

目的探讨核因子-κB（NF-κB）、增殖性细胞核抗原（PCNA）在宫颈癌组织中的表达及其意义。方法采用免疫组织化学方法，检测45例宫颈癌组织及30例正常宫颈组织中NF—κBp65、PCNA的表达。结果宫颈癌组织中NF-κBp65、PCNA表达率均明显高于正常组织（P〈0．05）。Ⅰb、Ⅱa期宫颈癌组织NF—κBp65、PCNA表达明显高于Ⅰa期宫颈癌组织（P〈0．05），低分化者表达明显高于中、高分化者（P〈0．05），有淋巴结转移者明显高于无淋巴结转移者（P〈0．05）；且NF-κBp65与PCNA的表达呈正相关（r=0．705，P〈0．05）。结论NF-κB、PCNA与宫颈癌的发病、侵袭和转移密切相关。

Objective To study the expression and significance of nuclear factor-kappa B （NF-κB） and proliferating cell nuclear antigen（PCNA） in uterine cervix cancer tissues. Methods The expression of NF-κB 1）65 and PCNA in the uterine cervix cancer tissues（ n =45） and normal cervix tissues（ n =30） were detected by immunohisto- chemistry method. Results The expression rate of NF-κB p65 and PCNA in the uterine cervix cancer tissues were significantly higher than that in normal cervix tissues （ P 〈 0. 05 ）. The expression of NF-κB p65 and PCNA in stage Ⅰ b, Ⅱ a were significantly higher than that in stage Ⅰ a （ P 〈 0. 05）, they were significantly higher in poorly differentiated than those in moderately differentiated, well-differentiated （ P 〈 0. 05 ）, they were significantly higher in existing lymphnode metastasis than those in non-existing lymphnode metastasis（ P 〈 0. 05 ） ;and the expression of NF-κB p65 was positively related to PCNA in uterine cervix cancer tissues （ r = 0. 705,P 〈 0. 05 ）. Conclusion The invasion,infestation and metastasis maybe dosely related to NF-κB and PCNA.