摘要
目的探讨核因子-κB(NF-κB)、增殖性细胞核抗原(PCNA)在宫颈癌组织中的表达及其意义。方法采用免疫组织化学方法,检测45例宫颈癌组织及30例正常宫颈组织中NF—κBp65、PCNA的表达。结果宫颈癌组织中NF-κBp65、PCNA表达率均明显高于正常组织(P〈0.05)。Ⅰb、Ⅱa期宫颈癌组织NF—κBp65、PCNA表达明显高于Ⅰa期宫颈癌组织(P〈0.05),低分化者表达明显高于中、高分化者(P〈0.05),有淋巴结转移者明显高于无淋巴结转移者(P〈0.05);且NF-κBp65与PCNA的表达呈正相关(r=0.705,P〈0.05)。结论NF-κB、PCNA与宫颈癌的发病、侵袭和转移密切相关。
Objective To study the expression and significance of nuclear factor-kappa B (NF-κB) and proliferating cell nuclear antigen(PCNA) in uterine cervix cancer tissues. Methods The expression of NF-κB 1)65 and PCNA in the uterine cervix cancer tissues( n =45) and normal cervix tissues( n =30) were detected by immunohisto- chemistry method. Results The expression rate of NF-κB p65 and PCNA in the uterine cervix cancer tissues were significantly higher than that in normal cervix tissues ( P 〈 0. 05 ). The expression of NF-κB p65 and PCNA in stage Ⅰ b, Ⅱ a were significantly higher than that in stage Ⅰ a ( P 〈 0. 05), they were significantly higher in poorly differentiated than those in moderately differentiated, well-differentiated ( P 〈 0. 05 ), they were significantly higher in existing lymphnode metastasis than those in non-existing lymphnode metastasis( P 〈 0. 05 ) ;and the expression of NF-κB p65 was positively related to PCNA in uterine cervix cancer tissues ( r = 0. 705,P 〈 0. 05 ). Conclusion The invasion,infestation and metastasis maybe dosely related to NF-κB and PCNA.
出处
《中国基层医药》
CAS
2009年第8期1353-1354,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
宫颈肿瘤
NF-ΚB
增殖性细胞核抗原
Uterine cervical neoplasms
NF kappa B
Proliferating cell nuclear antigen