急性心肌梗死患者血清基质金属蛋白酶-9和前胶原氨基末端肽水平变化

The clinicaI vaIue of MMP-9 and PIIINP in diagnosis of acute myocardial infarction

目的探讨急性心肌梗死患者血清基质金属蛋白酶-9（MMP-9）和Ⅲ型前胶原氨基末端肽（PII-INP）水平变化及其临床意义。方法检测76例心肌梗死患者（观察组）治疗前及治疗后血清MMP-9和PII—INP水平，并与选取的同期30例健康体检者相比较。结果观察组治疗前血清MMP-9（191．6±38．5）μg/L和PIIINP（8．9±1．8）μg／L水平明显高于对照组[（85．6±33．2）μg/L、（3．5±1．5）μg／L]（t=13．01、14．55，P〈0．05）；治疗后3d,7d、14d血清MMP-9[（170．2±30．2）μg／L、（123．6±32．7）μg／L、（90．2±30．2）μg／L]和PIIINP[（6．9±1．7）μg／L、（5．2±1．6）μg／L、（3．7±1．8）μg／L]水平逐渐降低与治疗前比较差异均有统计学意义（t=12．63、9．58、5．36、5．01、18．0、17．8，均P〈0．05），至治疗后14d血清中MMP-9（90．2±30．2）μg/L和PIIINP（3．7±1．8）μg／L水平至正常，与对照组比较差异无统计学意义（t=0．69、0．54，均P〉0．05）。结论MMP-9和PIIINP为临床诊断和治疗急性心肌梗死有指导意义。

Objective To investigate the clinical value of MMP-9 and PIIINP in diagnosis of acute myocardial infarction. Methods To retrospective analyze MMP-9 and PIIINP In 76 cases patients with acute myocardial infarction , when prophase and anaphase of treatment in our hospital. Results The MMP-9 （ 191.6 ± 38. 5 ） μg/L and PIIINP（ 8.9 ± 1.8） μ/L of observation group treatment prophase were higher than control group [ （85.6 ± 33.2 ） μg/ L, （3.5 ± 1.5） μg/L ], （ t = 13.01,14. 55, P 〈 0. 05 ）, which were obviously different between treatment anaphase 3d,7d, 14d MMP-9 [ （ 170. 2 ± 30.2）μg/L, （ 123.6 ± 32.7 ） μg/L, （ 90. 2 ± 30. 2 ） μg/L ] and PIIINP [ （ 6. 9 ± 1.7 ） μg/L, （5.2 ± 1.6） μg/L,3.7 ± 1.8） μg,/L] were lower than treatment prophase（ t = 12.63,9.58,5. 36,5.01,18.0, 17. 8, all P 〈 0. 05 ） ; the MMP-9 （ 90. 2 ± 30. 2 ） μg,/L and PIIINP （ 3.7 ± 1.8 ） μg/L were remove in treatment anaphase 14d,which had no difference between treatment anaphase 14d and treatment prophase（t =0.69,0.54,all P 〉 0. 05）. Conclusion The MMP-9 and PIIINP were higher diagnostic value in Clinical diagnosis acute myocardial infarction,which was worth to be used.