化疗栓塞术治疗肺癌临床研究

Chemoembolization with MMC-lipiodol or ADM-lipiodol mixture for the treatment of bronchogenic carcinoma

目的探讨经支气管动脉碘化油化疗栓塞治疗肺癌的临床价值。方法32例肺癌采用支气管动脉造影明确肿瘤供血血管，经导管给予氟尿嘧啶500～1000mg，顺铂60—80mg灌注后，用3—10ml碘化油＋丝裂霉素20mg或阿霉素40mg混合乳剂进行栓塞。结果近期疗效：完全缓解1例、部分缓解19例、稳定11例、进展1例，有效率62．5％（20／32）；并发症：胸痛5例，胸壁表皮痛2例，对症处理后均缓解，脊髓损伤1例，对症处理后部分恢复。结论支气管动脉碘化油栓塞治疗肺癌近期疗效较好，谨慎操作以防止严重并发症。

Objective To study the clinical value of transbronchial arterial chemoembolization with MMC-lipiodol or ADM-lipiodol mixture in the treatment of lung cancer. Methods In this study 32 cases with lung cancer, bronchial arteriography were adopted to identify the tumor-feeding branch. After perfusing 500 - 1 000rag 5-Fu and 60 -80mg CDDP through microcatheter,embolization with the mixture of 3 - 10ml lipiodol and 20mg MMC or 40mg ADM was performed. Results Short-term effectiveness：complete response（CR） was achieved in 1 case,while partial response（PR） in 19 cases,steady disease（SD） in 11 cases and process disease（PD） in 1 case. The total effectiverate （ CR plus PR） was up to 62. 5% （20/32）. Complications included 5 cases of the chest pain and 2 cases of the chest wall epidermis pain, which were relieved after symptomatic management. 1 case produced spinal injury, which was partially recovered after symptomatic management. Conclusion Transbronchial arterial chemoembolization with MMC-lipiodol or ADM-lipiodol mixture has good short-term effect in the treatment of lung cancer. The procedure should be carried out carefully to avoid severe complications.